Repositioning Candidate Details
| Candidate ID: | R0011 |
| Source ID: | DB00029 |
| Source Type: | approved |
| Compound Type: | biotech |
| Compound Name: | Anistreplase |
| Synonyms: | Anisoylated plasminogen streptokinase activator complex; Anistreplase; APSAC |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl group is chemically conjugated to a complex of bacterial-derived streptokinase and human Plasma-derived Lys-plasminogen proteins. |
| CAS Number: | 81669-57-0 |
| Molecular Weight: | |
| DrugBank Indication: | For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction |
| DrugBank Pharmacology: | Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction. |
| DrugBank MoA: | Anistreplase cleaves the Arg/Val bond in plasminogen to form plasmin. This in turn leads to the degradation of blood clots. |
| Targets: | Plasminogen activator; Fibrinogen alpha chain; Plasminogen activator inhibitor 1 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |