Repositioning Candidate Details
| Candidate ID: | R1103 |
| Source ID: | DB06795 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Mafenide |
| Synonyms: | 4-(aminomethyl)benzenesulfonamide; 4-Homosufanilamide; Bensulfamide; Mafenide; Maphenidum |
| Molecular Formula: | C7H10N2O2S |
| SMILES: | NCC1=CC=C(C=C1)S(N)(=O)=O |
| Structure: |
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| DrugBank Description: | Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. |
| CAS Number: | 138-39-6 |
| Molecular Weight: | 186.232 |
| DrugBank Indication: | Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | The precise mechanism of mafenide is unknown. However, mafenide reduces the bacterial population in the avascular burn tissue and promotes spontaneous heeling of deep burns. |
| Targets: | Carbonic anhydrase 6 antagonist |
| Inclusion Criteria: | Indication associated |
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