Repositioning Candidate Details
| Candidate ID: | R1154 |
| Source ID: | DB08808 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Bupranolol |
| Synonyms: | Bupranolol |
| Molecular Formula: | C14H22ClNO2 |
| SMILES: | CC1=CC(OCC(O)CNC(C)(C)C)=C(Cl)C=C1 |
| Structure: |
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| DrugBank Description: | Bupranolol is a non-selective beta blocker with potency similar to . It does not have intrinsic sympathomimetic activity (ISA), but does have strong membrane stabilizing activity. |
| CAS Number: | 14556-46-8 |
| Molecular Weight: | 271.783 |
| DrugBank Indication: | Used to manage hypertension and tachycardia. Also used to treat glaucoma. |
| DrugBank Pharmacology: | Bupranolol is a competitive, nonselective beta-blocker similar to propanolol without intrinsic sympathomimetic activity. |
| DrugBank MoA: | Bupranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. |
| Targets: | Beta-1 adrenergic receptor antagonist; Beta-2 adrenergic receptor antagonist; Beta-3 adrenergic receptor antagonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |