Repositioning Candidate Details
| Candidate ID: | R1176 |
| Source ID: | DB08880 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Teriflunomide |
| Synonyms: | (Z)-2-cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-p-crotonotoluidide; Teriflunomide |
| Molecular Formula: | C12H9F3N2O2 |
| SMILES: | C\C(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F |
| Structure: |
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| DrugBank Description: | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide. |
| CAS Number: | 163451-81-8 |
| Molecular Weight: | 270.2073 |
| DrugBank Indication: | Used in the treatment of relapsing forms of multiple sclerosis (MS). |
| DrugBank Pharmacology: | Teriflunomide is an immunomodulatory agent that decreases the amount of activated CNS lymphocytes, which results in anti-inflammatory and antiproliferative effects. |
| DrugBank MoA: | The exact mechanism by which teriflunomide acts in MS is not known. What is known is that teriflunomide prevents pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, and this may be involved in its immunomodulatory effect in MS. |
| Targets: | Dihydroorotate dehydrogenase (quinone), mitochondrial inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|