Repositioning Candidate Details
| Candidate ID: | R1178 |
| Source ID: | DB08887 |
| Source Type: | approved; investigational; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Icosapent ethyl |
| Synonyms: | (all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester; all-cis-ethyl 5,8,11,14,17-icosapentaenoate; cis-Eicosapentaenoic acid ethyl ester; E-EPA; Eicosapentaenoic acid ethyl ester; ethyl (5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate; ethyl (5Z,8Z,11Z,14Z,17Z)-icosapentaenoate; Ethyl (all cis)-5,8,11,14,17-icosapentaenoate; Ethyl all-cis-5,8,11,14,17-icosapentaenoate; Ethyl eicosapentaenoate; Ethyl icosapentate ; ethyl-eicosapentaenoic acid; Ethyl-EPA; Icosapent ethyl; Timnodonic acid ethyl ester |
| Molecular Formula: | C22H34O2 |
| SMILES: | CCOC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CC |
| Structure: |
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| DrugBank Description: | Icosapent ethyl or ethyl eicosapentaenoic acid is a synthetic derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA). It is used as adjunct therapy for severe hypertriglyceridemia (TG levels > 500 mg/dL). FDA approved on July 26, 2012. |
| CAS Number: | 86227-47-6 |
| Molecular Weight: | 330.5042 |
| DrugBank Indication: | Icosapent ethyl is used as adjunct therapy to reduce triglyceride (TG) levels in adults with severe (>500 mg/dL) hypertriglyceridemia. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Studies suggest that EPA reduces hepatic very low-density lipoprotein triglycerides (VLDL-TG) synthesis and/or secretion and enhances TG clearance from circulating VLDL particles. Potential mechanisms of action include increased β-oxidation; inhibition of acyl-CoA:1,2-diacylglycerol acyltransferase (DGAT); decreased lipogenesis in the liver; and increased plasma lipoprotein lipase activity. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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