Repositioning Candidate Details
| Candidate ID: | R0012 |
| Source ID: | DB00031 |
| Source Type: | approved |
| Compound Type: | biotech |
| Compound Name: | Tenecteplase |
| Synonyms: | Tenecteplase; TNK-tPA |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. |
| CAS Number: | 191588-94-0 |
| Molecular Weight: | |
| DrugBank Indication: | For treatment of myocardial infarction and lysis of intracoronary emboli |
| DrugBank Pharmacology: | Tenecteplase is a fibrin-specific tissue-plasminogen activator. It binds to fibrin rich clots and cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. This helps eliminate blood clots or arterial blockages that cause myocardial infarction. |
| DrugBank MoA: | Tenecteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. |
| Targets: | Plasminogen activator; Fibrinogen alpha chain; Urokinase plasminogen activator surface receptor; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor 2; Tetranectin; Keratin, type II cytoskeletal 8; Annexin A2; Calreticulin; Calnexin; Prolow-density lipoprotein receptor-related protein 1 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |