Repositioning Candidate Details
| Candidate ID: | R1245 |
| Source ID: | DB09214 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Dexketoprofen |
| Synonyms: | Dexketoprofen |
| Molecular Formula: | C16H14O3 |
| SMILES: | [H][C@@](C)(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Dexketoprofen is a non-steroidal anti-inflammatory drug. It is available in the various countries in Europe, Asia and Latin America. It has analgesic, antipyretic and anti-inflammatory properties . |
| CAS Number: | 22161-81-5 |
| Molecular Weight: | 254.2806 |
| DrugBank Indication: | For short-term treatment of mild to moderate pain, including dysmenorrhoea, musculoskeletal pain and toothache . |
| DrugBank Pharmacology: | This drug is an isomer of ketoprofen. Dexketoprofen a propionic acid derivative with analgesic, anti-inflammatory, and antipyretic properties . |
| DrugBank MoA: | It is a non-steroidal anti-inflammatory drug (NSAID) that reduces prostaglandin synthesis via inhibition of cyclooxygenase pathway (both COX-1 and COX-2) activity . |
| Targets: | Prostaglandin G/H synthase 1 antagonist; Prostaglandin G/H synthase 2 antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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