Repositioning Candidate Details
| Candidate ID: | R1246 |
| Source ID: | DB09215 |
| Source Type: | withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Droxicam |
| Synonyms: | -- |
| Molecular Formula: | C16H11N3O5S |
| SMILES: | CN1C2=C(OC(=O)N(C2=O)C2=CC=CC=N2)C2=CC=CC=C2S1(=O)=O |
| Structure: |
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| DrugBank Description: | Droxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of . It is used to reduce pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis. |
| CAS Number: | 90101-16-9 |
| Molecular Weight: | 357.34 |
| DrugBank Indication: | Droxicam is an NSAID previously used for the treatment of inflammation and rheumatoid arthritis . |
| DrugBank Pharmacology: | Droxicam is a prodrug of . Droxicam administration produces anti-inflammatory, antirheumatic, analgesic, and antipyretic effects similar to . |
| DrugBank MoA: | Droxicam is converted to via hydrolysis of the ester group in the intestine . Droxicam administration inhibits the synthesis of prostaglandins by cyclooxygenase enzymes . |
| Targets: | Prostaglandin G/H synthase 1 inhibitor; Prostaglandin G/H synthase 2 inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |