Repositioning Candidate Details
| Candidate ID: | R1248 |
| Source ID: | DB09218 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Clonixin |
| Synonyms: | Clonixin |
| Molecular Formula: | C13H11ClN2O2 |
| SMILES: | CC1=C(NC2=C(C=CC=N2)C(O)=O)C=CC=C1Cl |
| Structure: |
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| DrugBank Description: | Clonixin is a non-steroidal anti-inflammatory drug. |
| CAS Number: | 17737-65-4 |
| Molecular Weight: | 262.69 |
| DrugBank Indication: | Indicated for use in the management of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation. |
| DrugBank Pharmacology: | Clonixin is a non-steroidal anti-inflammatory drug (NSAID) similar in structure to . It produces vasodilation and analgesia. |
| DrugBank MoA: | The mechanism of clonixin does not appear to have been investigated on a molecular level. It is presumed to function similarly to other NSAIDs by inhibiting cycloxygenase enzymes 1 and 2 resulting in a reduction in prostaglandin production. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|