Repositioning Candidate Details
| Candidate ID: | R1262 |
| Source ID: | DB09243 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Hydracarbazine |
| Synonyms: | Hydracarbazine |
| Molecular Formula: | C5H7N5O |
| SMILES: | [H]N([H])N([H])C1=NN=C(C=C1)C(=O)N([H])[H] |
| Structure: |
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| DrugBank Description: | Hydracarbazine is a pyridazine that has found use as an antihypertensive agent It was once marketed in France under the tradename Normatensyl. |
| CAS Number: | 3614-47-9 |
| Molecular Weight: | 153.145 |
| DrugBank Indication: | Was used for the treatment of hypertension . |
| DrugBank Pharmacology: | Relaxes vascular smooth muscle . |
| DrugBank MoA: | Likely acts similarly to hydralazine, a related compound, which interferes with calcium release from the sarcoplasmic reticulum in response to inositol . |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |