Repositioning Candidate Details
| Candidate ID: | R1268 |
| Source ID: | DB09250 |
| Source Type: | withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Pheniprazine |
| Synonyms: | Pheniprazine |
| Molecular Formula: | C9H14N2 |
| SMILES: | CC(CC1=CC=CC=C1)NN |
| Structure: |
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| DrugBank Description: | Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. In addition, it was used for the treatment of other conditions, such as angina pectoris and schizophrenia. Pheniprazine was withdrawn by its manufacturer due to its ability to cause toxicity in the liver and its ability to cause optic neuritis. |
| CAS Number: | 55-52-7 |
| Molecular Weight: | 150.225 |
| DrugBank Indication: | For the treatment of depression, schizophrenia, and angina pectoris. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I17 | 1596 | Mental depression | Mental depression | disease of mental health/ cognitive disorder/ mood disorder | Details |