Repositioning Candidate Details
| Candidate ID: | R1279 |
| Source ID: | DB09276 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Sodium aurothiomalate |
| Synonyms: | Gold sodium thiomalate; Sodium aurothiomalate |
| Molecular Formula: | C4H3AuNa2O4S |
| SMILES: | [Na+].[Na+].[O-]C(=O)CC(S[Au])C([O-])=O |
| Structure: |
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| DrugBank Description: | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis. |
| CAS Number: | 12244-57-4 |
| Molecular Weight: | 390.07 |
| DrugBank Indication: | A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis. |
| DrugBank Pharmacology: | Unknown, may decrease prostaglandin synthesis or may alter cellular mechanisms by inhibiting sulfhydryl systems. |
| DrugBank MoA: | The precise mechanism of action is unknown. It is known that sodium aurothiomalate inhibits the synthesis of prostaglandins. The predominant action appears to be a suppressive effect on the synovitis of active rheumatoid disease. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |