Repositioning Candidate Details
| Candidate ID: | R1281 |
| Source ID: | DB09282 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Molsidomine |
| Synonyms: | Molsidomine |
| Molecular Formula: | C9H14N4O4 |
| SMILES: | CCOC(=O)[N-]C1=C[N+](=NO1)N1CCOCC1 |
| Structure: |
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| DrugBank Description: | Molsidomine is an orally active, long-acting vasodilator, which belongs to the class of medications known as syndnones. Interestingly, it is being studied as being a preventive measure in cerebral infarction . |
| CAS Number: | 25717-80-0 |
| Molecular Weight: | 242.235 |
| DrugBank Indication: | The indications for use of molsidomine include ischemic heart disease, angina, chronic heart failure, and pulmonary hypertension . |
| DrugBank Pharmacology: | Molsidomine leads to smooth muscle relaxation in the coronary blood vessels, relieving symptoms of angina and increasing blood flow to the coronary arteries. |
| DrugBank MoA: | Molsidomine, a cardiovascular drug, acts in a similar fashion to organic nitrates. The SIN-1A metabolite of molsidomine has a pharmacologically active group of nitric oxide, which increases levels of cyclic GMP, and decreases intracellular calcium ions in smooth muscle cells. This leads to relaxation of smooth muscle in the blood vessels, and inhibits platelet aggregation. |
| Targets: | Guanylate cyclase soluble subunit alpha-2 agonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |