Repositioning Candidate Details
| Candidate ID: | R1303 |
| Source ID: | DB09351 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Levobetaxolol |
| Synonyms: | (S)-betaxolol |
| Molecular Formula: | C18H29NO3 |
| SMILES: | CC(C)NC[C@H](O)COC1=CC=C(CCOCC2CC2)C=C1 |
| Structure: |
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| DrugBank Description: | Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued. |
| CAS Number: | 93221-48-8 |
| Molecular Weight: | 307.434 |
| DrugBank Indication: | Used in the treatment of open-angle glaucoma and ocular hypertension . |
| DrugBank Pharmacology: | Levobetaxolol is a selective β1 adrenergic receptor antagonist . It acts to lower intraocular pressure. Levobataxolol is condsidered to be the more active component of the betaxolol racemate. |
| DrugBank MoA: | The exact mechanism by which levobetaxolol lowers intraocular pressure is not known. It it thought that antagonism of β-adrenergic receptors may reduce the production of aqueous humour stimulated via the cyclic adenosine monophosphate-protein kinase A pathway . It is also thought that the vasoconstriction produced by antagonism of β adrenergic receptors reduces blood flow to the eye and therefore the ultrafiltration responsible for aqueous humour production. β1 selective antagonists are less effective than non-selective β adrenergic receptor antagonists because β2 receptors make up the bulk of the population in the eye. They do, however, come with the benefit of reduced respiratory complications. |
| Targets: | Beta-1 adrenergic receptor antagonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |