Repositioning Candidate Details
| Candidate ID: | R1312 |
| Source ID: | DB09462 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Glycerin |
| Synonyms: | 1,2,3-propanetriol; 1,2,3-trihydroxypropane; Glycerin; Glycerin, anhydrous; Glycerin,anhydrous; Glycerine; Glycerol; Monoctanoin component D; Propanetriol; Trihydroxypropane |
| Molecular Formula: | C3H8O3 |
| SMILES: | OCC(O)CO |
| Structure: |
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| DrugBank Description: | A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. |
| CAS Number: | 56-81-5 |
| Molecular Weight: | 92.0938 |
| DrugBank Indication: | It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent. |
| DrugBank Pharmacology: | Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes. |
| DrugBank MoA: | When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream. |
| Targets: | Peroxisome proliferator-activated receptor delta agonist; Group IIE secretory phospholipase A2; Inositol-3-phosphate synthase 1; Alcohol dehydrogenase 1B; Inositol 1,4,5-trisphosphate receptor type 1; Glycodelin; Alpha-N-acetylgalactosaminidase; ADP-ribosylation factor 1; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; DNA mismatch repair protein MutL; Ribonucleoside-diphosphate reductase 1 subunit beta; A/G-specific adenine glycosylase; tRNA (cytosine(38)-C(5))-methyltransferase; Maleylacetoacetate isomerase |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
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