Repositioning Candidate Details
| Candidate ID: | R1332 |
| Source ID: | DB11095 |
| Source Type: | approved |
| Compound Type: | biotech |
| Compound Name: | Desirudin |
| Synonyms: | 63-Desulfohirudin; 63-Desulfohirudin (Hirudo Medicinalis Isoform HV1); 63-Desulfohirudin (recombinant); Desirudin; Desirudin recombinant; Hirudin desirudin |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. Desirudin has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52. It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients. Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing. |
| CAS Number: | 120993-53-5 |
| Molecular Weight: | |
| DrugBank Indication: | Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery. |
| DrugBank Pharmacology: | Desirudin results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT). |
| DrugBank MoA: | Desirudin is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT). |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
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