Repositioning Candidate Details
| Candidate ID: | R1334 |
| Source ID: | DB11107 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Potassium bitartrate |
| Synonyms: | Potassium bitartrate; potassium hydrogen tartrate |
| Molecular Formula: | C4H5KO6 |
| SMILES: | [K+].O[C@H]([C@@H](O)C([O-])=O)C(O)=O |
| Structure: |
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| DrugBank Description: | Potassium bitartate, also referred to as potassium acid tartrate or cream of tartar, is the potassium acid salt of l-( + )-tartaric acid. It is obtained as a byproduct of wine manufacture during the fermentation process. Approved by the FDA as a direct food substance, potassium bitartrate is used as an additive, stabilizer, pH control agent, antimicrobial agent, processing aid, or thickener in various food products . Potassium bitartrate has a long history of medical use as a laxative administered as a rectal suppository and is an approved third-class OTC drug in Japan. Potassium bitartrate was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. |
| CAS Number: | 868-14-4 |
| Molecular Weight: | 188.176 |
| DrugBank Indication: | Indicated for the treatment of constipation. |
| DrugBank Pharmacology: | Potassium bitartrate potentiates bowel movements. In medical studies, it was shown to be an effective treatment for chronic constipationwhen combined with sodium bicarbonate in a polyethylene glycol-based suppository . |
| DrugBank MoA: | Potassium bitartrate is a carbon dioxide-releasing laxative that works by forming carbon dioxide gas, which creates a mechanical distension against the intestinal wall and induces bowel contractions. Rectal suppositories of carbon dioxide-releasing type of laxative were demonstrated to be useful and safe in the treatment of patients at risk for electrolyte disorders such as the elderly or patients with renal or cardiovascular disorders . |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
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