Repositioning Candidate Details
| Candidate ID: | R1336 |
| Source ID: | DB11113 |
| Source Type: | approved; investigational; nutraceutical; vet_approved |
| Compound Type: | biotech |
| Compound Name: | Castor oil |
| Synonyms: | Agaliya oil; Bimayou; Castor oil; Castorbean oil; Cataputia major oil; Cataputia minor oil; Croton spinosus oil; Lama palagi oil; Maskerekur oil; Oleum ricini; Ricinus africanus oil; Ricinus angulatus oil; Ricinus armatus oil; Ricinus atropurpureus oil; Ricinus badius oil; Ricinus borboniensis oil; Ricinus cambodgensis oil; Ricinus communis (castor) seed oil; Ricinus communis castor seed oil; Ricinus communis fibre oil; Ricinus communis oil; Ricinus communis seed oil; Ricinus compactus oil; Ricinus digitatus oil; Ricinus europaeus oil; Ricinus gibsonii oil; Ricinus giganteus oil; Ricinus glaucus oil; Ricinus hybridus oil; Ricinus inermis oil; Ricinus japonicus oil; Ricinus krappa oil; Ricinus laevis oil; Ricinus lividus oil; Ricinus macrocarpus oil; Ricinus macrophyllus oil; Ricinus medicus oil; Ricinus medius oil; Ricinus messeniacus oil; Ricinus metallicus oil; Ricinus microcarpus oil; Ricinus minor oil; Ricinus nanus oil; Ricinus obermannii oil; Ricinus oil; Ricinus peltatus oil; Ricinus perennis oil; Ricinus persicus oil; Ricinus purpurascens oil; Ricinus ruber oil; Ricinus rugosus oil; Ricinus rutilans oil; Ricinus sanguineus oil; Ricinus scaber oil; Ricinus speciosus oil; Ricinus spectabilis oil; Ricinus tunisensis oil; Ricinus undulatus oil; Ricinus urens oil; Ricinus viridis oil; Ricinus vulgaris oil; Ricinus zanzibarensis oil; Ricinus zanzibarinus; Toto ni vavalagi oil; Uluchula skoki oil |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic, and less than 1% linolenic fatty acids . has a hydroxyl group that provides a functional group location for various chemical reactions, making it a favourable substance in industrial applications . Castor oil does not contain ricin, which is a natural poison found in the castor oil plant; the toxic lectin remains in the bean pulp following oil isolation . Due to its renewability and high versatility in addition to being the only commercial source of a hydroxylated fatty acid , castor oil has been used as a vital raw material for the chemical industry . Castor oil was mainly used in the manufacturing of soaps, lubricants, and coatings . It is an FDA-approved food additive directly added to food products for human consumption. It can also be found in hard candies as a release agent and anti-sticking agent, or supplementary vitamins and mineral oral tablets as an ingredient for protective coatings. Castor oil is found in over-the-counter oral liquids as a stimulant laxative, and is also added in commercial cosmetic, hair, and skincare products. |
| CAS Number: | 8001-79-4 |
| Molecular Weight: | |
| DrugBank Indication: | Indicated for over-the-counter use as a laxative for oral use and as a soothing agent for topical use on skin and hair. |
| DrugBank Pharmacology: | Castor oil is a potent laxative that was shown to be effective for short-term constipation. In a prospective study, the group receiving oral castor oil was associated with a higher likelihood of initiation of labour compared to the placebo group . Castor oil is known to induce diarrhea, and has been used in studies to assess anti-diarrheal effect of some compounds . |
| DrugBank MoA: | Castor oil is a mix of triglycerides consisting of mainly ricinolein, linoleic acid, oleic acid, palmitic acid, stearic acid, dihydroxystearic acid, and traces of other fatty acids . The main pharmacodynamic effects of castor oil are mediated by ricinoleic acid, a hydroxylated fatty acid released from castor oil by intestinal lipases . It was believed that ricinoleic acid acts as an anionic surfactant that reduces net absorption of fluid and electrolytes, and stimulates intestinal peristalsis . However, a recent study suggests that ricinoleic acid interacts with EP3 prostanoid receptors expressed on intestinal and uterine smooth muscles. Via activating EP3 prostanoid receptors on intestinal and uterine smooth muscle cells, ricinoleic acid promotes laxation and uterus contraction, respectively . EP3 receptor act as the major prostanoid receptor in the intestine mediating propulsive effects on gut motility, and activation of EP3 receptors has been demonstrated to evoke contraction of uterine smooth muscle . |
| Targets: | Prostaglandin E2 receptor EP3 subtype agonist&activator; Prostaglandin E2 receptor EP4 subtype agonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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