Repositioning Candidate Details
| Candidate ID: | R1339 |
| Source ID: | DB11120 |
| Source Type: | approved; experimental |
| Compound Type: | small molecule |
| Compound Name: | Turpentine |
| Synonyms: | Gum turpentine; Spirits of gum turpentine; Turpentine (gum); Turpentine gum |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is composed of terpenes, mainly the monoterpenes alpha-pinene and beta-pinene with lesser amounts of carene, camphene, dipentene, and terpinolene. |
| CAS Number: | 9005-90-7 |
| Molecular Weight: | |
| DrugBank Indication: | Turpentine has been used experimentally in a bath for the treatment of disseminated sclerosis and sexual dysfunction. It also has been studied for its antibacterial activity and inhibition of osteoclast activity. Turpentine is utilized in experimental models of inflammation to induce a systemic inflammatory immune response in animals. |
| DrugBank Pharmacology: | Turpentine oil, when inhaled, may help reduce congestion. When used on the skin, turpentine oil may cause warmth and redness that can help relieve pain in the tissue underneath. |
| DrugBank MoA: | Binding of turpentine oil or inflammatory cytokines e.g. interleukin-1 (IL-1) activate signalling through the IL-1 Type 1 receptor (IL-1 R1). Initiation occurs by binding of Toll-interleukin 1 receptor adaptor protein (TIRAP) and Myeloid differentiation primary response gene 88 (mD88) which then dissociates and interacts with IRAK (Interleukin 1 receptor associated kinase) and the tumour necrosis factor receptor associated factor 6 (TRAF6). This activates the MAPK pathway leading to transcription of the nuclear factor κB transcription factor and production of inflammatory mediators. |
| Targets: | Mitogen-activated protein kinase 1 |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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