Repositioning Candidate Details
| Candidate ID: | R1343 |
| Source ID: | DB11134 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Cupric oxide |
| Synonyms: | Cuprous Oxide; Cuprum oxydatum nigrum |
| Molecular Formula: | CuO |
| SMILES: | [O--].[Cu++] |
| Structure: |
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| DrugBank Description: | Cupric oxide, or copper (II) oxide, is an inorganic compound with the chemical formula CuO. Cupric oxide is used as a precursor in many copper-containing products such as wood preservatives and ceramics. Cupric oxide may be found in over-the-counter vitamin-mineral supplements as a source of . The mean daily dietary intake of copper in adults ranges between 0.9 and 2.2 mg . Common routes of cupric oxide exposure include ingestion, dermal exposure and inhalation. Copper(II) oxide nanoparticles (NPCuO) have industrial applications as antimicrobial agents in textiles and paints, and catalysts in organic synthesis . They may also be produced from electronic wastes. Cupric oxide poses potential health and environmental concern due to toxic and mutagenic particles generating reactive oxygen species . |
| CAS Number: | 1317-38-0 |
| Molecular Weight: | 79.545 |
| DrugBank Indication: | No FDA- or EMA-approved therapeutic indications. |
| DrugBank Pharmacology: | For pharmacodynamic information of copper, refer to drug entry for . Copper(II) oxide nanoparticles are known to generate reactive oxygen species (ROS), leading to cytotoxicity . In a comparative toxicity assay, nanoparticles caused significant mitochondrial depolarization leading to DNA damage . In the human skin organ culture study, topical application of copper oxide (CuO) nanoparticles induced inflammatory cytokine secretion and necrosis _in vitro_, indicating that the nanoparticles may adhere to the skin surface and react with the local acidic environment . |
| DrugBank MoA: | For pharmacodynamic information of copper, refer to drug entry for . Copper(II) oxide nanoparticles generate DNA-damaging reactive oxygen species at the nanoparticle surface or in solution by copper dissolved from the nanoparticle surface via Fenton-like reactions . In presence of H2O2, ascorbate, or both, copper (II) oxide generates hydroxyl radical, ascorbyl radical, and superoxide anion that interact with DNA, proteins, and lipids cause oxidative damage and cell death . |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
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