Repositioning Candidate Details
| Candidate ID: | R1349 |
| Source ID: | DB11201 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Menthyl salicylate |
| Synonyms: | 1-Menthyl salicylate; Menthyl salicylate, (+/-)- |
| Molecular Formula: | C17H24O3 |
| SMILES: | CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1O |
| Structure: |
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| DrugBank Description: | Menthyl salicylate is an ester of menthol and salicylic acid . This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) . |
| CAS Number: | 89-46-3 |
| Molecular Weight: | 276.376 |
| DrugBank Indication: | For the temporary relief of pain associated with rheumatism, arthritis, neuralgia, sprains and strains of joints and muscles, lumbago and fibrositis . |
| DrugBank Pharmacology: | Menthol and methyl salicylate are known as counterirritants. They work by causing the skin to feel cool and then warm. Used together, they provide symptomatic relief for mild to moderate muscular and joint aches and pains, muscle cramps, shoulder aches and stiff neck.. |
| DrugBank MoA: | Menthol dilates the blood vessels causing a sensation of coldness, followed by an analgesic effect. Menthol also acts as a penetration enhancer, increasing the penetration of drugs when applied on the skin, to give a faster onset of action . Methyl salicylate is a salicylic acid derivative, and when combined with menthol, produces menthyl salicylate . Salicylates inhibit cyclooxygenase, thereby reducing the formation of prostaglandins, and cause platelet dysfunction Methyl salicylate is used topically as a counter-irritant. Upon application, it is absorbed through the skin and is applied for the relief of pain in rheumatic conditions and painful muscle or joints . The menthol dilates blood vessels, why the salicylate portion provides a topical anesthetic and analgesic action on the affected area. The cooling and warning action may interfere with the transmission of pain signals through nerves . |
| Targets: | Prostaglandin G/H synthase 1 antagonist; Prostaglandin G/H synthase 2 antagonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |