Repositioning Candidate Details
| Candidate ID: | R1351 |
| Source ID: | DB11207 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Amiloxate |
| Synonyms: | 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester; Amiloxate; Isoamyl p-methoxycinnamate; Isoamyl-p-methoxycinnamate |
| Molecular Formula: | C15H20O3 |
| SMILES: | COC1=CC=C(\C=C\C(=O)OCCC(C)C)C=C1 |
| Structure: |
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| DrugBank Description: | Amiloxate is an EMA-approved chemical UV-filter found in over-the-counter sunscreen products at concentrations up to 10%m . It is often referred to as isoamyl 4-methoxycinnamate or isoamyl p-methoxycinnamate. Amiloxate is a cinnamic acid derivative with an anti-inflammatory activity . |
| CAS Number: | 71617-10-2 |
| Molecular Weight: | 248.322 |
| DrugBank Indication: | Indicated as an active sunscreen agent. |
| DrugBank Pharmacology: | In a mouse study, amiloxate exerted a dose-dependent anti-inflammatory action and inhibited edema by about 70% even at a low dose . Due to structural similarities, amiloxate may also display antioxidant and antimicrobial properties of cinnamic acid . |
| DrugBank MoA: | Amiloxate is a UV-B filter that selectively absorbs UV-B rays . It is proposed that amiloxate mediates an antioxidant action by acting as a free radical scavenger . |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|