Repositioning Candidate Details
| Candidate ID: | R1354 |
| Source ID: | DB11228 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Methylcellulose |
| Synonyms: | Cellulose methyl; cellulose methyl ether; Cellulose methylate; Methyl cellulose; methylated cellulose; Methylcellulose |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values are 1.3 2.6. Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic |
| CAS Number: | 9004-67-5 |
| Molecular Weight: | |
| DrugBank Indication: | Solutions containing methyl cellulose are used as substitute for tears or saliva if the natural production of these fluids is disturbed. It is also used or constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. Used in the manufacture of capsules in nutritional supplements. Its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin. |
| DrugBank Pharmacology: | It increases the bulk in your stool, an effect that helps to cause movement of the intestines. It also works by increasing the amount of water in the stool, making the stool softer and easier to pass. |
| DrugBank MoA: | Methylcellulose absorbs water in the gastrointestinal lumen thereby increasing the bulk of the stool. This leads to distension and stimulation of peristalsis. The ability of methylcellulose to absorb water may contribute to its efficacy in the management of diarrhea by once again increasing the bulk and consistency of the stool. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
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