Repositioning Candidate Details
| Candidate ID: | R1361 |
| Source ID: | DB11269 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Diethylamino hydroxybenzoyl hexyl benzoate |
| Synonyms: | Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate |
| Molecular Formula: | C24H31NO4 |
| SMILES: | CCCCCCOC(=O)C1=CC=CC=C1C(=O)C1=CC=C(C=C1O)N(CC)CC |
| Structure: |
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| DrugBank Description: | Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions . Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S., South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability . It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers . |
| CAS Number: | 302776-68-7 |
| Molecular Weight: | 397.515 |
| DrugBank Indication: | Indicated for use as a sunscreen agent. |
| DrugBank Pharmacology: | Diethylamino hydroxybenzoyl hexyl benzoate is an organic UV filter that attenuates the exposure of UV radiation on human skin . _In vitro_, topical application of diethylamino hydroxybenzoyl hexyl benzoate exerted an anti-inflammatory effect on inflammation-evoked mouse ears by inhibiting oedema formation . |
| DrugBank MoA: | Diethylamino hydroxybenzoyl hexyl benzoate absorbs in the UV-A range with the peak at 354 nm . |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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