Repositioning Candidate Details
| Candidate ID: | R1362 |
| Source ID: | DB11296 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Prezatide |
| Synonyms: | GHK; Gly-His-Lys; Glycyl-L-histidyl-L-lysine; Glycylhistidyllysine; Growth-modulating peptide (human); Liver cell growth factor; Tripeptide-1 |
| Molecular Formula: | C14H24N6O4 |
| SMILES: | NCCCC[C@H](NC(=O)[C@H](CC1=CNC=N1)NC(=O)CN)C(O)=O |
| Structure: |
|
| DrugBank Description: | Prezatide is a tripeptide consisting of glycine, histidine, and lysine which readily forms a complex with copper ions . Prezatide is used in cosmetic products for the skin and hair. It is known to aid wound healing and its potential applications in chronic obstructive pulmonary disease and metastatic colon cancer are currently being investigated. |
| CAS Number: | 49557-75-7 |
| Molecular Weight: | 340.384 |
| DrugBank Indication: | Commonly used in cosmetic products for the skin and hair . |
| DrugBank Pharmacology: | Prezatide in complex with copper improve skin elasticity, density, and firmness, reduces fine lines and wrinkles, reduces photodamage, increases keratinocyte proliferation . Prezatide also displays anti-oxidant and angiogenic effects and appears to modulate tissue remodeling in injury. |
| DrugBank MoA: | Prezatide in complex with copper increases the synthesis and deposition of type I collagen and glycosaminoglycan . It also increases the expression of matrix metalloproteinase-2 as well as tissue inhibitor of matrix metalloproteinases-1 and -2, suggesting that it plays a role in the modulation of tissue remodeling . It is thought that prezatide's antioxidant activity is due to its ability to supply copper for superoxide dismutase and its anti inflammatory ability due to the blockage the of iron (Fe2+) release during injury . Prezatide also increases angiogenesis to injury sites. The precise mechanisms of these effects are unknown. It is also unknown whether prezatide's effects are due to the action of the tripeptide itself or its ability to localize and transport copper . Prezatide is known to be bound by heparin and heparin sulfate |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|