Repositioning Candidate Details
| Candidate ID: | R1371 |
| Source ID: | DB11365 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Sennosides |
| Synonyms: | Senna glycosides; Sennoside; Sennosides |
| Molecular Formula: | C42H38O20 |
| SMILES: | OCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O |
| Structure: |
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| DrugBank Description: | Sennosides (also known as senna glycoside or senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Sennoside A, one of the sennosides present in the laxative medication, has recently proven effective in inhibiting the ribonuclease H (RNase H) activity of human immunodeficiency virus (HIV) reverse transcriptase . |
| CAS Number: | 517-43-1 |
| Molecular Weight: | 862.746 |
| DrugBank Indication: | For the over the counter treatment of constipation. |
| DrugBank Pharmacology: | Senna stimulates peristalsis and increases fecal water content to increase motility of feces through the large intestine. |
| DrugBank MoA: | Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone . Rheinanthrone appears to increase cyclooxegenase 2 (COX2) expression in macrophage cells leading to an increase in prostaglandin E2 (PGE2). This increase in PGE2 is associated with a decrease in aquaporin 3 expression in mucosal epithelial cells of the large intestine. A decrease in aquaporin 3 expression likely produces the laxative effect by restricting water reabsorption by the large intestine thereby increasing fecal water content. The exact mechanism by which rheinanthrone increases COX2 expression is unknown. Rheinanthrone also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown. Rhein , another active metabolite is thought to excite submucosal acetylcholinergic neurons resulting in increased chloride and prostaglandin secretion. The movement of chloride ions into the large intestine would also help to draw water into the lumen. |
| Targets: | Aquaporin-3 inhibitor; Reverse transcriptase/RNaseH inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
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