Repositioning Candidate Details
| Candidate ID: | R1372 |
| Source ID: | DB11367 |
| Source Type: | withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Cefroxadine |
| Synonyms: | Cefroxadine |
| Molecular Formula: | C16H19N3O5S |
| SMILES: | [H][C@]12SCC(OC)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CCC=CC1)C(O)=O |
| Structure: |
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| DrugBank Description: | Cefroxadine is an orally available cephalosporin antibiotic. As part of its drug class, it shares structural properties to as well as its activity spectrum. It was used in Italy but has since been withdrawn. |
| CAS Number: | 51762-05-1 |
| Molecular Weight: | 365.4 |
| DrugBank Indication: | Was used for the treatment of bacterial infections. |
| DrugBank Pharmacology: | Cefroxadine is a cephalosporin antibiotic which produces a bactericidal effect on susceptible bacteria . |
| DrugBank MoA: | Cefrixadine is a cephalosporin antibiotic, a class of β-lactam antibiotics similar to penicillins, which binds to and inhibits penicillin binding proteins (PBPs) . PBPs are responsible for catalyzing the transpeptidase reaction which cross-links the peptide side chains on the sugar residues of a peptidoglycan unit, adding the unit to the peptidoglycan layer. This disrupts the balance between the hydrolysis of peptidoglycan, in order to insert new peptidoglycan units, by murein hydrolase and the attachment of the new units which leads to overall destruction of the peptidoglycan layer. With the loss of its peptidoglycan layer the cell also loses its resistance to the high osmotic pressure inside its membrane and lyses. |
| Targets: | Penicillin-binding protein 1B inhibitor |
| Inclusion Criteria: | Indication associated |
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