Repositioning Candidate Details
| Candidate ID: | R1445 |
| Source ID: | DB12364 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Betrixaban |
| Synonyms: | Betrixaban; N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide; N-(5-chloropyridin-2-yl)-2-[[4-(N,N-dimethylcarbamimidoyl)benzoyl]amino]-5-methoxybenzamide |
| Molecular Formula: | C23H22ClN5O3 |
| SMILES: | COC1=CC=C(NC(=O)C2=CC=C(C=C2)C(=N)N(C)C)C(=C1)C(=O)NC1=CC=C(Cl)C=N1 |
| Structure: |
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| DrugBank Description: | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals Inc., is prescribed as a venous thromboembolism (VTE) prophylactic for adult patients with moderate to severe restricted motility or with other risks for VTE . VTE can be manifested as deep vein thrombosis or pulmonary embolism and it is a leading cause of preventable death in hospitalized patients . |
| CAS Number: | 330942-05-7 |
| Molecular Weight: | 451.91 |
| DrugBank Indication: | Betrixaban is indicated for prophylaxis of venous thromboembolism (VTE) in conditions of moderate to severe restricted mobility or in patients that qualify as in risk of VTE. |
| DrugBank Pharmacology: | Betrixaban is an oral anticoagulant that excerts its action by preventing thrombin generation without having a direct effect on platelet aggregation . |
| DrugBank MoA: | Betrixaban is a cofactor-independent direct inhibitor of the Factor Xa and inhibits free and prothrombinase-bound Factor Xa . |
| Targets: | Coagulation factor X inhibitor |
| Inclusion Criteria: | Therapeutic strategy associated |
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