Repositioning Candidate Details
| Candidate ID: | R1487 |
| Source ID: | DB13179 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Troleandomycin |
| Synonyms: | Oleandocetine; Oleandomycin triacetate; Oleandomycin triacetyl ester; Triacetyloleandomycin; Tribiocillina; Troleandomycin |
| Molecular Formula: | C41H67NO15 |
| SMILES: | CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]3(CO3)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(C)=O |
| Structure: |
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| DrugBank Description: | A macrolide antibiotic that is similar to erythromycin. |
| CAS Number: | 2751-09-9 |
| Molecular Weight: | 813.9684 |
| DrugBank Indication: | For the treatment of bacterial infection. |
| DrugBank Pharmacology: | Troleandomycin, like other macrolide antibiotics, inhibits bacterial protein synthesis to prevent growth. |
| DrugBank MoA: | As a macrolide, troleandomycin binds to the 50S subunit of the bacterial ribosome . This binding inhibits translocation of tRNA along the A, P, and E sites of the ribosome. With tRNA unable to move from site to site, amino acids cannot be deposited onto the polypeptide chain leading to failure of protein synthesis. Bacterial cell growth and duplication is inhibited without the ability to generate the necessary proteins. |
| Targets: | 50S ribosomal protein L32 inhibitor; 50S ribosomal protein L4 inhibitor; Nuclear receptor subfamily 1 group I member 2 activator |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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