Repositioning Candidate Details
| Candidate ID: | R1500 |
| Source ID: | DB13908 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Amylmetacresol |
| Synonyms: | 5-methyl-2-pentylphenol; 6-amyl-m-cresol; 6-n-amyl-m-cresol; 6-n-pentyl-m-cresol; 6-pentyl-m-cresol; Amyl metacresol; Amylmetacresol |
| Molecular Formula: | C12H18O |
| SMILES: | CCCCCC1=CC=C(C)C=C1O |
| Structure: |
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| DrugBank Description: | Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils . The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition . |
| CAS Number: | 1300-94-3 |
| Molecular Weight: | 178.275 |
| DrugBank Indication: | Sore throat, minor mouth and throat infections , , . |
| DrugBank Pharmacology: | The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission . In addition, it relieves symptoms of sore throat/irritation of the throat , . Amylmetacresol is thought to inhibit the inflammatory and pain mediators that are involved in the inflammation of the mouth and throat mucous membranes, as well as the sore throat . |
| DrugBank MoA: | The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action . Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner . |
| Targets: | Sodium channel protein type 2 subunit alpha antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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