Repositioning Candidate Details
| Candidate ID: | R1523 |
| Source ID: | DB14513 |
| Source Type: | approved; experimental; investigational |
| Compound Type: | small molecule |
| Compound Name: | Magnesium |
| Synonyms: | Magnesium metallicum; Magnesium powder; Mg |
| Molecular Formula: | H2Mg |
| SMILES: | [MgH2] |
| Structure: |
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| DrugBank Description: | Magnesium is classified as an alkaline earth metal and has 2 hydration shells. The element can be found in abundance in the hydrosphere and in mineral salts such as dolomite and magnesium carbonate. Common dietary sources of magnesium include nuts (cashews, peanuts, almonds), beans, bananas, apples, carrots, broccoli, and leafy greens. Magnesium is an important enzyme cofactor and is essential to several metabolic processes. Further, the mineral helps regulate blood pressure and is necessary for RNA, DNA and protein synthesis among several other functions. Despite the importance of magnesium and its availability via several food sources, an estimated 56 to 68% of adults who live in developed, western countries do not meet the recommended daily intake (RDI) of magnesium. Several factors and common behaviours reduce the availability of magnesium in the diet such as food processing and cooking vegetables (which are normally a rich source of magnesium). |
| CAS Number: | 7439-95-4 |
| Molecular Weight: | 26.321 |
| DrugBank Indication: | Healthy levels of magnesium can be achieved through a well balanced diet, but if food sources are insufficient, magnesium supplements can be used to prevent and treat magnesium deficiencies. In medicine, various magnesium salts may be used in laxative and antacid products. For example, is available over-the-counter and may be used to manage occasional constipation. may be used on its own or with total parenteral nutrition to treat hypomagnesemia. is also indicated to prevent seizures in pregnant women with pre-eclampsia, and to manage seizures associated with eclampsia. |
| DrugBank Pharmacology: | Magnesium is important for many biochemical processes and is therefore quite common in humans. The majority of magnesium is stored in the bones (>50%), while the remainder is stored in muscle, soft tissue, red blood cells and serum. This is functionally important since the bones behave as a magnesium exchange reservoir and help maintain healthy levels of magnesium. Magnesium plays an important role in the regulation of several bodily processes including blood pressure, insulin metabolism, muscular contraction, vasomotor tone, cardiac excitability, nerve transmission and neuromuscular conduction. Disruptions in homeostatic levels of magnesium (often times hypomagnesemia) can impact the nervous system, muscles, or can lead to cardiac abnormalities. |
| DrugBank MoA: | Magnesium is a cofactor for at least 300 enzymes and is important for several functions in the body with some key processes identified below. Enzymes that rely on magnesium to operate help produce energy through oxidative phosphorylation, glycolysis and ATP metabolism. They are also involved in nerve function, muscle contraction, blood glucose control, hormone receptor binding, protein synthesis, cardiac excitability, blood pressure control, gating of calcium channels and transmembrane ion flux. The mitochondrial intracellular space is rich in magnesium, since it is required to produce the active form of ATP (adenosine triphosphate) from ADP (adenosine diphosphate) and inorganic phosphate, and behaves as a counter ion for the energy rich molecule. Additionally, magnesium is essential for ATP metabolism. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
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