Repositioning Candidate Details
| Candidate ID: | R1539 |
| Source ID: | DB14684 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Calcium polycarbophil |
| Synonyms: | Calcium polycarbophil; Polycarbophil calcium; Polycarbophil, calcium |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Calcium polycarbophil is a stool stabilizer. Based on its chemical structure, it is a synthetic polymer of polyacrylic acid cross-linked with divinyl glycol presenting a calcium atom as a counter-ion. Polycarbophil is used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali. The material possesses exceptionally high water-binding capacity. is not absorbed, does not interfere with the activity of digestive enzymes or intestinal absorption, possesses satisfactory stability, is physiologically inert, and does not cause gastrointestinal irritation. |
| CAS Number: | 126040-58-2 |
| Molecular Weight: | |
| DrugBank Indication: | Polycarbophil is used to treat constipation and to help maintain regular bowel movements. |
| DrugBank Pharmacology: | Relieves constipation or diarrhea associated with bowel disorders and acute nonspecific diarrhea. |
| DrugBank MoA: | It is known as a bulk-forming laxative. It increases the bulk in the stool, an effect that helps to cause movement of the intestines. It also works by increasing the amount of water in the stool, making the stool softer and easier to pass. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
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