Repositioning Candidate Details
| Candidate ID: | R1572 |
| Source ID: | DB15724 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | Human umbilical cord blood mononuclear cell-conditioned medium |
| Synonyms: | Umbilical Cord Blood Mononuclear Cells Conditioned Medium |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Transplantation with human umbilical cord blood mononuclear cells (HUCBC) has demonstrated promising results in various disease states. While some of the positive results are credited to HUCBCs’ differentiation potential, the growth factors and cytokines these cells secrete are also implicated. When HUCBCs secrete growth factors and anti-inflammatory cytokines, they are thought to reduce inflammation and associated damage. Thus, the media in which they are cultured is believed to also have therapeutic potential. After the human umbilical cord mononuclear cells are extracted from the umbilical cord, they are expanded and cultured in Dulbecco’s modified Eagle’s medium. Then, the medium is filtered and separated from the HUCBCs. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Mononuclear umbilical cord cells have the ability to secrete cytokines, growth factors, interleukins,and chemokines. As many of these factors can have anti-inflammatory, angiogenic, and neuroprotective effects, it is thought that the conditioned media may exert some therapeutic potential related to these effects. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|