Repositioning Candidate Details
| Candidate ID: | R1578 |
| Source ID: | DB15745 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | Washed Microbiota Transplantation |
| Synonyms: | WMT |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Fecal microbiota transplantation (FMT) is effective in enhancing the gut microbiota of patients experiencing a high range of disease states, including Clostridioides difficile (C. diff) infection, Crohn’s disease, and ulcerative colitis. Washed microbiota preparation (WMT) involves a method wherein FMT is used, but the preparation undergoes microfiltration through an automatic purification system combined with repeated centrifugation and suspension. Fecal particles, parasite eggs, fungus and other potentially harmful things are removed. The resulting suspension is shown to decrease FMT-related adverse events. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | WMT delivers a precise dose of enriched microbiota through intraperitoneal injection, oral capsule, nasogastric tube, nasojeunal tube, or anal enema. The transplantation of the materials within the WMT is thought to recolonize the gut bacteria and aid in treating patient pathology associated with disease like Crohn’s, and ulcerative colitis. WMT is being investigated as a rescue therapy for critically ill patients with COVID-19. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |