Repositioning Candidate Details
| Candidate ID: | R1593 |
| Source ID: | DB16366 |
| Source Type: | investigational |
| Compound Type: | biotech |
| Compound Name: | F-652 |
| Synonyms: | IL-22 fusion protein |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | F-652 is a recombinant IL-22-Fc fusion protein manufactured in Chinese hamster ovary cells that is composed of 2 human interleukin 22 (IL-22) molecules linked to an immunoglobulin constant region (IgG2-Fc). It is being developed by Evive Biotech (previously known as Generon BioMed Inc). |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | F-652 incorporates human interleukin 22’s (IL-22) natural epithelial cell growth-promoting activity as IL-22 plays critical roles in promoting tissue repair and suppressing bacterial infection. F-652 is currently being investigated against acute graft vs host disease, acute alcoholic hepatitis, inflammatory diseases, organ injuries, eventual fatal organ failures, and COVID-19. |
| Targets: | -- |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I01 | 552 | Pneumonia | A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://en.wikipedia.org/wiki/Pneumonia | disease of anatomical entity/respiratory system disease/ lower respiratory tract disease/lung disease | Details |