Repositioning Candidate Details
| Candidate ID: | R0280 |
| Source ID: | DB00785 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Cryptenamine |
| Synonyms: | -- |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Cryptenamine is a mixture of closely related hypotensive alkaloids from Veratrum album (Liliaceae). It has been used in the treatment of hypertension but has largely been replaced by drugs with fewer adverse effects. Cryptenamine has a marked and re-producible depressor effect when given intravenously to hypertensive patients, however the mechanism of action is not known. |
| CAS Number: | 1356-18-9 |
| Molecular Weight: | |
| DrugBank Indication: | For the treatment of hypertension. |
| DrugBank Pharmacology: | Cryptenamine is a mixture of closely related hypotensive alkaloids from <i>Veratrum album</i> (Liliaceae). It has been used in the treatment of hypertension but has largely been replaced by drugs with fewer adverse effects. |
| DrugBank MoA: | Cryptenamine has a marked and re-producible depressor effect when given intravenously to hypertensive patients, however the mechanism of action is not known. Some evidence has suggested that cryptenamine acts in a similar fashion to atropine, which lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system. This occurs because atropine is a competitive inhibitor of the muscarinic acetylcholine receptors (acetylcholine is the neurotransmitter used by the parasympathetic nervous system). Therefore muscarinic acetylcholine receptors will be listed as experimental targets for cryptenamine. |
| Targets: | Muscarinic acetylcholine receptor M2 antagonist; Beta adrenergic receptor inhibitor&potentiator |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |