Repositioning Candidate Details
| Candidate ID: | R0284 |
| Source ID: | DB00800 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Fenoldopam |
| Synonyms: | -- |
| Molecular Formula: | C16H16ClNO3 |
| SMILES: | OC1=CC=C(C=C1)C1CNCCC2=C(Cl)C(O)=C(O)C=C12 |
| Structure: |
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| DrugBank Description: | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. |
| CAS Number: | 67227-56-9 |
| Molecular Weight: | 305.756 |
| DrugBank Indication: | For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. |
| DrugBank Pharmacology: | Fenoldopam is an agonist at D<sub>1</sub>-like dopamine receptors, binds to α<sub>2</sub>-adrenoceptors, increasing renal blood flow. |
| DrugBank MoA: | Fenoldopam is a rapid-acting vasodilator. It is an agonist for D<sub>1</sub>-like dopamine receptors and binds with moderate affinity to α<sub>2</sub>-adrenoceptors. It has no significant affinity for D<sub>2</sub>-like receptors, α<sub>1</sub> and β-adrenoceptors, 5<sub>HT1</sub> and 5<sub>HT2</sub> receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D<sub>1</sub>-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D<sub>2</sub>-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration. |
| Targets: | Dopamine D5 receptor agonist; Dopamine D1 receptor agonist; Alpha-2B adrenergic receptor antagonist; Alpha-2C adrenergic receptor antagonist; Alpha-2A adrenergic receptor antagonist; Alpha-1B adrenergic receptor inhibitor; Alpha-1D adrenergic receptor inhibitor; Alpha-1A adrenergic receptor inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |