Repositioning Candidate Details
| Candidate ID: | R0286 |
| Source ID: | DB00804 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Dicyclomine |
| Synonyms: | 2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate; Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester; Dicyclomine; Dicycloverin; Dicycloverine |
| Molecular Formula: | C19H35NO2 |
| SMILES: | CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1 |
| Structure: |
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| DrugBank Description: | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome. Though it is commonly prescribed, its recommendation may have been based on a small amount of evidence and so its prescription is becoming less favourable. Dicyclomine was granted FDA approval on 11 May 1950. |
| CAS Number: | 77-19-0 |
| Molecular Weight: | 309.4867 |
| DrugBank Indication: | Dicyclomine is indicated for the treatment of functional bowel disorder and irritable bowel syndrome. |
| DrugBank Pharmacology: | Dicyclomine is an anticholinergic drug used to relax the smooth muscles of the intestines. It's duration of action is not especially long as it is usually taken 4 times daily with individual doses of 20-40mg orally or 10-20mg by intramuscular injection. Dicyclomine should not be administered intravenously. |
| DrugBank MoA: | Dicyclomine achieves its action partially through direct antimuscarinic activity of the M1, M3, and M2 receptors; and partially through antagonism of bradykinin and histamine. Dicyclomine non-competitively inhibits the action of bradykinin and histamine, resulting in direct action on the smooth muscle, and decreased strength of contractions seen in spasms of the ileum. |
| Targets: | Muscarinic acetylcholine receptor M1 antagonist; Muscarinic acetylcholine receptor M3 antagonist; Muscarinic acetylcholine receptor M2 antagonist |
| Inclusion Criteria: | Indication associated |
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