Repositioning Candidate Details
| Candidate ID: | R0295 |
| Source ID: | DB00824 |
| Source Type: | approved; experimental |
| Compound Type: | small molecule |
| Compound Name: | Enprofylline |
| Synonyms: | 3-n-propylxanthine; 3-Propyl-3,7-dihydro-purine-2,6-dione; 3-propylxanthine; 3,7-dihydro-3-propyl-1H-purine-2,6-dione; Enprofylline |
| Molecular Formula: | C8H10N4O2 |
| SMILES: | CCCN1C2=C(NC=N2)C(=O)NC1=O |
| Structure: |
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| DrugBank Description: | Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. Long-term enprofylline administration may be associated with elevation in liver enzyme levels and unpredictable blood levels. |
| CAS Number: | 41078-02-8 |
| Molecular Weight: | 194.1906 |
| DrugBank Indication: | Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. |
| DrugBank Pharmacology: | Enprofylline is a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine. It antagonizes erythrocyte phosphodiesterase, increasing cAMP activity. |
| DrugBank MoA: | Enprofylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, enprofylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. |
| Targets: | cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor; cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor; Adenosine receptor A2b antagonist; Adenosine receptor A1 inhibitor; Adenosine receptor A2a inhibitor; Adenosine receptor A3 inhibitor |
| Inclusion Criteria: | Indication associated |
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