Repositioning Candidate Details
| Candidate ID: | R0298 |
| Source ID: | DB00830 |
| Source Type: | approved; illicit |
| Compound Type: | small molecule |
| Compound Name: | Phenmetrazine |
| Synonyms: | 2-phenyl-3-methylmorpholine; Fenmetrazin; Phenmetrazin; Phenmetrazine |
| Molecular Formula: | C11H15NO |
| SMILES: | CC1NCCOC1C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | A sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. |
| CAS Number: | 134-49-6 |
| Molecular Weight: | 177.2429 |
| DrugBank Indication: | Used as an anorectic in the treatment of obesity. |
| DrugBank Pharmacology: | Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. Its actions and mechanisms are similar to dextroamphetamine. Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. Phenmetrazine was originally sold under the tradename Preludin as an anorectic. It has since been removed from the market. It is by some considered to have a greater potential for addiction than the amphetamines, and has been abused in many countries, for example Sweden. |
| DrugBank MoA: | Phenmetrazine is thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron leading to an increase in the release of these monoamines into the extraneuronal space. Dopamine integrates incoming sensory stimuli, initiates and controls fine movement (nigro-neostriatal pathway), controls emotional behavior (midbrain mesolimbic-forebrain system) and controls hypothalamic-pituitary endocrine system (tubero-infundibular system). It is this latter effect on the tubero-infundibular systm that seems to lead to reduced food intake. Phenmetrazine also acts as a monoamine oxidase inhibitor. |
| Targets: | Sodium-dependent noradrenaline transporter inhibitor; Sodium-dependent dopamine transporter inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |