Repositioning Candidate Details
| Candidate ID: | R0323 |
| Source ID: | DB00883 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Isosorbide dinitrate |
| Synonyms: | 1,4:3,6-Dianhydrosorbitol 2,5-dinitrate; D-Isosorbide dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dinitroisosorbide; Dinitrosorbide; ISDN; Isosorbide 2,5-dinitrate; Isosorbide dinitrate; Sorbide nitrate; Sorbidnitrate |
| Molecular Formula: | C6H8N2O8 |
| SMILES: | [H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O |
| Structure: |
|
| DrugBank Description: | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. |
| CAS Number: | 87-33-2 |
| Molecular Weight: | 236.1363 |
| DrugBank Indication: | For the prevention of angina pectoris due to coronary artery disease. |
| DrugBank Pharmacology: | Isosorbide Dinitrate is a moderate to long acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure. |
| DrugBank MoA: | Isosorbide dinitrate is converted to the active nitric oxide to activate guanylate cyclase. This activation increases levels of cyclic guanosine 3',5'-monophosphate (cGMP). cGMP activates protein kinases and causes a series of phosphorylation reactions which leads to dephosphorylation of myosin light chains of smooth muscle fibres. Finally there is a release of calcium ions which causes smooth muscle relaxation and vasodilation. |
| Targets: | Atrial natriuretic peptide receptor 1 agonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |