Repositioning Candidate Details
| Candidate ID: | R0335 |
| Source ID: | DB00925 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Phenoxybenzamine |
| Synonyms: | Fenossibenzamina; Phenoxybenzamine; POB |
| Molecular Formula: | C18H22ClNO |
| SMILES: | CC(COC1=CC=CC=C1)N(CCCl)CC1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. |
| CAS Number: | 59-96-1 |
| Molecular Weight: | 303.826 |
| DrugBank Indication: | For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension. |
| DrugBank Pharmacology: | Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure. |
| DrugBank MoA: | Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. |
| Targets: | Alpha-1A adrenergic receptor antagonist; Alpha-2A adrenergic receptor antagonist; Alpha-2C adrenergic receptor antagonist; Alpha-2B adrenergic receptor antagonist; Calmodulin inhibitor; Beta-2 adrenergic receptor; Alpha-1B adrenergic receptor antagonist; Alpha-1D adrenergic receptor antagonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |