Repositioning Candidate Details
| Candidate ID: | R0341 |
| Source ID: | DB00940 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Methantheline |
| Synonyms: | Methantheline; Methantheline cation; Methantheline ion; Methanthelinium; Methanthelinum |
| Molecular Formula: | C21H26NO3 |
| SMILES: | CC[N+](C)(CC)CCOC(=O)C1C2=CC=CC=C2OC2=CC=CC=C12 |
| Structure: |
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| DrugBank Description: | Methantheline is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children). |
| CAS Number: | 5818-17-7 |
| Molecular Weight: | 340.436 |
| DrugBank Indication: | For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children. |
| DrugBank Pharmacology: | Methantheline is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Methantheline inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites. |
| DrugBank MoA: | Methantheline inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder. |
| Targets: | Muscarinic acetylcholine receptor M1 antagonist; Histamine H2 receptor antagonist; Muscarinic acetylcholine receptor M2; Muscarinic acetylcholine receptor M3; Muscarinic acetylcholine receptor M4; Muscarinic acetylcholine receptor M5 |
| Inclusion Criteria: | Indication associated |
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