Repositioning Candidate Details
| Candidate ID: | R0036 |
| Source ID: | DB00120 |
| Source Type: | approved; investigational; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Phenylalanine |
| Synonyms: | (S)-2-Amino-3-phenylpropionic acid; (S)-alpha-Amino-beta-phenylpropionic acid; 3-phenyl-L-alanine; beta-Phenyl-L-alanine; F; L-Phenylalanine; Phe; Phenylalanine; β-phenyl-L-alanine |
| Molecular Formula: | C9H11NO2 |
| SMILES: | N[C@@H](CC1=CC=CC=C1)C(O)=O |
| Structure: |
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| DrugBank Description: | Phenylalanine is an essential aromatic amino acid that is a precursor of melanin, , (norepinephrine), and . |
| CAS Number: | 63-91-2 |
| Molecular Weight: | 165.1891 |
| DrugBank Indication: | L-phenylalanine may be helpful in some with depression. It may also be useful in the treatment of vitiligo. There is some evidence that L-phenylalanine may exacerbate tardive dyskinesia in some schizophrenic patients and in some who have used neuroleptic drugs. |
| DrugBank Pharmacology: | Used by the brain to produce Norepinephrine, a chemical that transmits signals between nerve cells and the brain; keeps you awake and alert; reduces hunger pains; functions as an antidepressant and helps improve memory. |
| DrugBank MoA: | The supposed antidepressant effects of L-phenylalanine may be due to its role as a precursor in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects. <br/>The mechanism of L-phenylalanine's possible antivitiligo activity is not well understood. It is thought that L-phenylalanine may stimulate the production of melanin in the affected skin |
| Targets: | Tyrosine aminotransferase; Large neutral amino acids transporter small subunit 2; Phenylalanine--tRNA ligase alpha subunit; Phenylalanine-4-hydroxylase; Phenylalanine--tRNA ligase, mitochondrial; Phenylalanine--tRNA ligase beta subunit; Tyrosine 3-monooxygenase binder |
| Inclusion Criteria: | Indication associated |
