Repositioning Candidate Details
| Candidate ID: | R0398 |
| Source ID: | DB01090 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Pentolinium |
| Synonyms: | Pentolineum; Pentolonium; Pentolonum |
| Molecular Formula: | C15H32N2 |
| SMILES: | C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1 |
| Structure: |
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| DrugBank Description: | Pentolinium is a nicotinic antagonist that has been used as a ganglionic blocking agent in hypertension. |
| CAS Number: | 144-44-5 |
| Molecular Weight: | 240.428 |
| DrugBank Indication: | Used to produce controlled hypotension during surgical procedures and in hypertensive crises. |
| DrugBank Pharmacology: | Pentolinium acts as a ganglionic blocking agent. Pentolinium inhibits release of adrenaline and noradrenaline from adrenergic nerves. It is used as an antihypertensive, and can be administered orally, intramuscularly, and subcutaneously. |
| DrugBank MoA: | Pentolinium binds to the nicotinic (ganglion) acetylcholine receptor. This receptor/channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. Blockage of the receptor leads to smooth muscle relaxation and vasodilaton. |
| Targets: | Neuronal acetylcholine receptor subunit alpha-10 antagonist; Neuronal acetylcholine receptor subunit alpha-3 antagonist; Neuronal acetylcholine receptor subunit beta-4 antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |