Repositioning Candidate Details
| Candidate ID: | R0399 |
| Source ID: | DB01092 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Ouabain |
| Synonyms: | 3-(α-L-rhamnopyranosyloxy)-1β,5β,11α,14,19-pentahydroxy-5β-card-20(22)-enolide; G-Strophanthin; Ouabagenin L-Rhamnoside; Ouabain anhydrous; Ouabaine; Oubain |
| Molecular Formula: | C29H44O12 |
| SMILES: | [H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O |
| Structure: |
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| DrugBank Description: | A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. |
| CAS Number: | 630-60-4 |
| Molecular Weight: | 584.6525 |
| DrugBank Indication: | For the treatment of atrial fibrillation and flutter and heart failure |
| DrugBank Pharmacology: | Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. |
| DrugBank MoA: | Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential. |
| Targets: | Sodium/potassium-transporting ATPase subunit alpha-1 inhibitor; Sodium/potassium-transporting ATPase subunit alpha-2 inhibitor; Sodium/potassium-transporting ATPase subunit alpha-3 inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |