Repositioning Candidate Details
| Candidate ID: | R0004 |
| Source ID: | DB00009 |
| Source Type: | approved |
| Compound Type: | biotech |
| Compound Name: | Alteplase |
| Synonyms: | Alteplase; Alteplase (genetical recombination); Alteplase, recombinant; Alteplase,recombinant; Plasminogen activator (human tissue-type protein moiety); rt-PA; t-PA; t-plasminogen activator; Tissue plasminogen activator; Tissue plasminogen activator alteplase; Tissue plasminogen activator, recombinant; tPA |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells |
| CAS Number: | 105857-23-6 |
| Molecular Weight: | |
| DrugBank Indication: | For management of acute myocardial infarction, acute ischemic stroke and for lysis of acute pulmonary emboli. |
| DrugBank Pharmacology: | Alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. It also produces limited conversion of plasminogen in the absence of fibrin. |
| DrugBank MoA: | Alteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. |
| Targets: | Plasminogen activator; Fibrinogen alpha chain; Urokinase plasminogen activator surface receptor; Plasminogen activator inhibitor 1 |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |