Repositioning Candidate Details
| Candidate ID: | R0401 |
| Source ID: | DB01094 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Hesperetin |
| Synonyms: | (−)-(S)-hesperetin; (−)-hesperetin; (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 3',5,7-Trihydroxy-4'-methoxyflavanone; Hesperitin |
| Molecular Formula: | C16H14O6 |
| SMILES: | COC1=C(O)C=C(C=C1)[C@@H]1CC(=O)C2=C(O)C=C(O)C=C2O1 |
| Structure: |
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| DrugBank Description: | Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside , is the predominant flavonoid in lemons and oranges. |
| CAS Number: | 520-33-2 |
| Molecular Weight: | 302.2788 |
| DrugBank Indication: | For lowering cholesterol and, possibly, otherwise favorably affecting lipids. <i>In vitro</i> research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again. |
| DrugBank Pharmacology: | Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions. |
| DrugBank MoA: | Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT<sub>1</sub> and ACAT<sub>2</sub>) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels. |
| Targets: | Sterol O-acyltransferase 1 inhibitor; Sterol O-acyltransferase 2 inhibitor; Microsomal triglyceride transfer protein large subunit antagonist; Sex hormone-binding globulin |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
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