Repositioning Candidate Details
| Candidate ID: | R0411 |
| Source ID: | DB01116 |
| Source Type: | approved; investigational |
| Compound Type: | small molecule |
| Compound Name: | Trimethaphan |
| Synonyms: | Thimethaphan; Trimetaphan; Trimetaphanum |
| Molecular Formula: | C22H25N2OS |
| SMILES: | O=C1N(CC2=CC=CC=C2)C2C[S+]3CCCC3C2N1CC1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | A nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. |
| CAS Number: | 7187-66-8 |
| Molecular Weight: | 365.512 |
| DrugBank Indication: | For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. |
| DrugBank Pharmacology: | Trimethaphan is indicated for production of controlled hypotension during surgery to reduce bleeding into the surgical field and also for rapid reduction of blood pressure in the treatment of hypertensive emergencies, especially in patients with acute dissecting aneurysm, and in the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension. |
| DrugBank MoA: | Trimethaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimethaphan's hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural. |
| Targets: | Neuronal acetylcholine receptor subunit alpha-10 antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |