Repositioning Candidate Details
| Candidate ID: | R0414 |
| Source ID: | DB01119 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Diazoxide |
| Synonyms: | Diazoxide |
| Molecular Formula: | C8H7ClN2O2S |
| SMILES: | CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2 |
| Structure: |
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| DrugBank Description: | A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. |
| CAS Number: | 364-98-7 |
| Molecular Weight: | 230.671 |
| DrugBank Indication: | Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma. |
| DrugBank Pharmacology: | Diazoxide is a potassium channel activator. Its mechanism of action revolves around enhancing cell membrane permeability to potassium ions. This action consequently elicits the relaxation of local smooth muscles. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential. |
| DrugBank MoA: | Diazoxide inhibits insulin release from the pancreas, by opening potassium channels in the beta cell membrane. Diazoxide is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity. It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance. |
| Targets: | ATP-sensitive inward rectifier potassium channel 11 inducer; Carbonic anhydrase 1 inhibitor; Carbonic anhydrase 2 inhibitor; Sodium/potassium-transporting ATPase subunit alpha-1 other; Calcium-activated potassium channel subunit alpha-1 other |
| Inclusion Criteria: | Indication associated |
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